| 2021-10-17 09:00:00October 17, 2021 |   Colts vs Chargers | 09:00:009:00 am | 28 - 35 | Aurora Sports Dome |
| 2021-10-17 10:00:00October 17, 2021 |   Steelers vs Vikings | 10:00:0010:00 am | 7 - 42 | Aurora Sports Dome |
| 2021-10-17 11:00:00October 17, 2021 |   Jaguars vs Cardinals | 11:00:0011:00 am | 49 - 28 | Aurora Sports Dome |
| 2021-10-24 09:00:00October 24, 2021 | Chargers vs Jaguars | 09:00:009:00 am | 42 - 35 | Aurora Sports Dome |
| 2021-10-24 10:00:00October 24, 2021 | Vikings vs Cardinals | 10:00:0010:00 am | 49 - 14 | Aurora Sports Dome |
| 2021-10-24 11:00:00October 24, 2021 | Steelers vs Colts | 11:00:0011:00 am | 35 - 28 | Aurora Sports Dome |
| 2021-10-31 09:00:00October 31, 2021 | Vikings vs Jaguars | 09:00:009:00 am | 42 - 42 | Aurora Sports Dome |
| 2021-10-31 10:00:00October 31, 2021 | Cardinals vs Colts | 10:00:0010:00 am | 35 - 49 | Aurora Sports Dome |
| 2021-10-31 11:00:00October 31, 2021 | Steelers vs Chargers | 11:00:0011:00 am | 42 - 35 | Aurora Sports Dome |
| 2021-11-07 09:00:00November 7, 2021 | Chargers vs Cardinals | 09:00:009:00 am | 21 - 28 | Aurora Sports Dome |
| 2021-11-07 10:00:00November 7, 2021 | Colts vs Vikings | 10:00:0010:00 am | 49 - 42 | Aurora Sports Dome |
| 2021-11-07 11:00:00November 7, 2021 | Jaguars vs Steelers | 11:00:0011:00 am | 42 - 49 | Aurora Sports Dome |
| 2021-11-14 09:00:00November 14, 2021 | Colts vs Jaguars | 09:00:009:00 am | 35 - 49 | Aurora Sports Dome |
| 2021-11-14 10:00:00November 14, 2021 | Vikings vs Chargers | 10:00:0010:00 am | 35 - 28 | Aurora Sports Dome |
| 2021-11-14 11:00:00November 14, 2021 | Cardinals vs Steelers | 11:00:0011:00 am | 35 - 7 | Aurora Sports Dome |
| 2021-11-21 09:00:00November 21, 2021 | Cardinals vs Jaguars | 09:00:009:00 am | 21 - 42 | Aurora Sports Dome |
| 2021-11-21 10:00:00November 21, 2021 | Chargers vs Colts | 10:00:0010:00 am | 35 - 42 | Aurora Sports Dome |
| 2021-11-21 11:00:00November 21, 2021 | Vikings vs Steelers | 11:00:0011:00 am | 28 - 42 | Aurora Sports Dome |
| 2021-11-28 09:00:00November 28, 2021 | Colts vs Steelers | 09:00:009:00 am | 14 - 42 | Aurora Sports Dome |
| 2021-11-28 10:00:00November 28, 2021 | Jaguars vs Chargers | 10:00:0010:00 am | 35 - 42 | Aurora Sports Dome |
| 2021-11-28 11:00:00November 28, 2021 | Cardinals vs Vikings | 11:00:0011:00 am | 35 - 28 | Aurora Sports Dome |
| 2021-12-05 09:00:00December 5, 2021 | Colts vs Cardinals | 09:00:009:00 am | 42 - 14 | Aurora Sports Dome |
| 2021-12-05 10:00:00December 5, 2021 | Chargers vs Steelers | 10:00:0010:00 am | 49 - 35 | Aurora Sports Dome |
| 2021-12-05 11:00:00December 5, 2021 | Jaguars vs Vikings | 11:00:0011:00 am | 21 - 35 | Aurora Sports Dome |
| 2021-12-12 09:00:00December 12, 2021 | Steelers vs Jaguars | 09:00:009:00 am | 35 - 28 | Aurora Sports Dome |
| 2021-12-12 10:00:00December 12, 2021 | Cardinals vs Chargers | 10:00:0010:00 am | 21 - 35 | Aurora Sports Dome |
| 2021-12-12 11:00:00December 12, 2021 | Vikings vs Colts | 11:00:0011:00 am | 42 - 56 | Aurora Sports Dome |
| 2022-02-06 09:00:00February 6, 2022 | Chargers vs Vikings | 09:00:009:00 am | 42 - 28 | Aurora Sports Dome |
| 2022-02-06 10:00:00February 6, 2022 | Jaguars vs Colts | 10:00:0010:00 am | 28 - 49 | Aurora Sports Dome |
| 2022-02-06 11:00:00February 6, 2022 | Steelers vs Cardinals | 11:00:0011:00 am | 21 - 28 | Aurora Sports Dome |
| 2022-02-13 09:00:00February 13, 2022 | Colts vs Cardinals | 09:00:009:00 am | 42 - 35 | Aurora Sports Dome |
| 2022-02-13 10:00:00February 13, 2022 | Jaguars vs Chargers | 10:00:0010:00 am | 21 - 21 | Aurora Sports Dome |
| 2022-02-13 11:00:00February 13, 2022 | Steelers vs Vikings | 11:00:0011:00 am | 34 - 28 | Aurora Sports Dome |
